Macrophage Scavenger Receptor 1 Protein (MSR1) (AA 77-451) (His tag)

Catalog No. ABIN7538370

Product Details

Target: Macrophage Scavenger Receptor 1 (MSR1)

Protein Type: Recombinant

Protein Characteristics: AA 77-451

Origin: Human

Source: Mammalian Cells

Purification tag / Conjugate: This Macrophage Scavenger Receptor 1 protein is labelled with His tag.

Purpose: Recombinant human MSR1 Protein with N-terminal 6xHis tag

Specificity: 6xHis tag MSR1 (Lys77-Leu451)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: MSR1 (MSR1 Products)

Synonyms: CD204 Protein, SCARA1 Protein, SR-A Protein, SRA Protein, phSR1 Protein, phSR2 Protein, MRS-A Protein, MSR Protein, MSR-A Protein, SR-AI Protein, SR-AII Protein, Scara1 Protein, Scvr Protein, MSR1 Protein, RGD1564316 Protein, macrophage scavenger receptor 1 Protein, scavenger receptor class A member 5 Protein, MSR1 Protein, Msr1 Protein, SCARA5 Protein

Background: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Molecular Weight: predicted molecular mass of 42.1 kDa after removal of the signal peptide.

UniProt: P21757