LPAR5 Protein

Catalog No. ABIN7538368

Product Details

Target: LPAR5 (Lysophosphatidic Acid Receptor 5 (LPAR5))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human LPAR5 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: LPAR5 (Lysophosphatidic Acid Receptor 5 (LPAR5))

Alternative Name: LPAR5 (LPAR5 Products)

Synonyms: LPA5 Protein, GPR92 Protein, GPR93 Protein, KPG_010 Protein, LPAR5 Protein, Gpr92 Protein, RGD1562580 Protein, Gm1072 Protein, zgc:194481 Protein, zgc:194493 Protein, lpar6l Protein, p2ry5 Protein, wu:fb62d01 Protein, zgc:66034 Protein, lysophosphatidic acid receptor 5 Protein, lysophosphatidic acid receptor 5b Protein, lysophosphatidic acid receptor 5a Protein, LPAR5 Protein, Lpar5 Protein, lpar5 Protein, lpar5b Protein, lpar5a Protein

Background: This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

Molecular Weight: The human full length LPAR5 protein has a MW of 41.3kDa

UniProt: Q9H1C0