LPAR3 Protein

Catalog No. ABIN7538366

Product Details

Target: LPAR3 (Lysophosphatidic Acid Receptor 3 (LPAR3))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human LPAR3 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: LPAR3 (Lysophosphatidic Acid Receptor 3 (LPAR3))

Alternative Name: LPAR3 (LPAR3 Products)

Synonyms: EDG7 Protein, Edg-7 Protein, GPCR Protein, HOFNH30 Protein, LP-A3 Protein, LPA3 Protein, RP4-678I3 Protein, Edg7 Protein, lpA3 Protein, lysophosphatidic acid receptor 3 Protein, LPAR3 Protein, LOC100038016 Protein, Lpar3 Protein

Background: This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length LPAR3 protein has a MW of 40.1kDa

UniProt: Q9UBY5

Pathways: Regulation of Cell Size