LPAR1 Protein

Catalog No. ABIN7538364

Product Details

Target: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human LPAR1 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Alternative Name: LPAR1 (LPAR1 Products)

Synonyms: EDG2 Protein, GPR26 Protein, Gpcr26 Protein, LPA1 Protein, Mrec1.3 Protein, VZG1 Protein, edg-2 Protein, rec.1.3 Protein, vzg-1 Protein, Edg2 Protein, EDG-2 Protein, 5031439C20 Protein, AI326300 Protein, Kdt2 Protein, lpA1 Protein, edg2 Protein, si:dz22b13.1 Protein, si:dz46m7.1 Protein, zgc:92157 Protein, LPA receptor 1-A Protein, LPA-1-A Protein, gpr26 Protein, lpa1 Protein, lpa1r Protein, lpa1r1 Protein, lpar1 Protein, lpar1-a Protein, lpar1-b Protein, vzg1 Protein, xLPA1-1 Protein, LPA receptor 1-B Protein, LPA-1-B Protein, edg2-A Protein, xLPA1-2 Protein, xlpa1R Protein, lysophosphatidic acid receptor 1 Protein, lysophosphatidic acid receptor 1 S homeolog Protein, lysophosphatidic acid receptor 1 L homeolog Protein, LPAR1 Protein, Lpar1 Protein, lpar1 Protein, lpar1.S Protein, lpar1.L Protein

Background: The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]

Molecular Weight: The human full length LPAR1 protein has a MW of 41.1kDa

UniProt: Q92633

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration