KISS1R Protein

Catalog No. ABIN7538351

Product Details

Target: KISS1R (KISS1 Receptor (KISS1R))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human KISSR full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: KISS1R (KISS1 Receptor (KISS1R))

Alternative Name: KISSR (KISS1R Products)

Synonyms: AXOR12 Protein, CPPB1 Protein, GPR54 Protein, HH8 Protein, HOT7T175 Protein, KISS-1R Protein, Gpr54 Protein, KiSS-1 Protein, gpr54 Protein, gpr54-1 Protein, gpr54a Protein, kiss1r Protein, kiss1rl Protein, kissr2 Protein, si:dkey-31m5.9 Protein, axor12 Protein, kissr1a Protein, KISS1 receptor Protein, KISS1 receptor a Protein, KISS1R Protein, Kiss1r Protein, kiss1ra Protein, kiss1r Protein

Background: The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length KISSR protein has a MW of 42.6kDa

UniProt: Q969F8