IGF1R Protein (AA 31-936) (His tag)

Catalog No. ABIN7538331

Product Details

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Protein Type: Recombinant

Protein Characteristics: AA 31-936

Origin: Mouse

Source: Mammalian Cells

Purification tag / Conjugate: This IGF1R protein is labelled with His tag.

Purpose: Recombinant mouse IGF-1R protein with C-terminal 6xHis tag

Specificity: Mouse IGF-1R (Glu31-His936) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF-1R (IGF1R Products)

Synonyms: CMT2N Protein, CD221 Protein, IGFIR Protein, IGFR Protein, JTK13 Protein, IGFIRC Protein, IGFR1 Protein, IGF-1R Protein, IGF1R Protein, DKFZp469I0618 Protein, igf-1r Protein, xIGF-1R Protein, xIGFR Protein, xigf1r Protein, A330103N21Rik Protein, D930020L01 Protein, hyft Protein, igf-ir Protein, IGF-IR Protein, IGF-IRb Protein, wu:fb03h06 Protein, IGF-IRa Protein, sb:eu1090 Protein, wu:fi20b10 Protein, alanyl-tRNA synthetase Protein, insulin like growth factor 1 receptor Protein, insulin-like growth factor 1 receptor Protein, insulin-like growth factor 1 Protein, insulin-like growth factor I receptor Protein, insulin like growth factor 1 receptor S homeolog Protein, insulin-like growth factor 1b receptor Protein, insulin-like growth factor 1a receptor Protein, AARS Protein, IGF1R Protein, Igf1r Protein, igf1r Protein, Igf1 Protein, LOC780503 Protein, LOC100136427 Protein, igf1r.S Protein, igf1rb Protein, igf1ra Protein

Background: Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development, positive regulation of cold-induced thermogenesis, and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development, peptidyl-tyrosine autophosphorylation, and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, limb, and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple), kidney cancer (multiple), liver disease (multiple), nervous system cancer (multiple), and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Molecular Weight: predicted molecular mass of 104.5 kDa after removal of the signal peptide.

UniProt: Q60751

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy