HCRTR2 Protein

Catalog No. ABIN7538326

Product Details

Target: HCRTR2 (Hypocretin (Orexin) Receptor 2 (HCRTR2))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human OX2R full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: HCRTR2 (Hypocretin (Orexin) Receptor 2 (HCRTR2))

Alternative Name: OX2R (HCRTR2 Products)

Synonyms: LOC100229747 Protein, LOC443181 Protein, hcrtr Protein, OX2R Protein, mOX2aR Protein, mOX2bR Protein, mOXR2 Protein, hypocretin receptor 2 Protein, hypocretin (orexin) receptor 2 Protein, HCRTR2 Protein, hcrtr2 Protein, Hcrtr2 Protein

Background: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

Molecular Weight: The human full length OX2R protein has a MW of 50.7kDa

UniProt: O43614

Pathways: Feeding Behaviour