GPR45 Protein

Catalog No. ABIN7538277

Product Details

Target: GPR45 (G Protein-Coupled Receptor 45 (GPR45))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human GPR45 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: GPR45 (G Protein-Coupled Receptor 45 (GPR45))

Alternative Name: GPR45 (GPR45 Products)

Synonyms: GPR45 Protein, MGC97852 Protein, PSP24 Protein, PSP24(ALPHA) Protein, PSP24A Protein, 9230112G11Rik Protein, AW046772 Protein, LPA Protein, lpar-a Protein, xpsp24 Protein, G protein-coupled receptor 45 Protein, G protein-coupled receptor 45 L homeolog Protein, GPR45 Protein, gpr45 Protein, Gpr45 Protein, gpr45.L Protein

Background: This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

Molecular Weight: The human full length GPR45 protein has a MW of 42kDa

UniProt: Q9Y5Y3