FZD3 Protein

Catalog No. ABIN7538245

Product Details

Target: FZD3 (Frizzled Family Receptor 3 (FZD3))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human FZD3 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: FZD3 (Frizzled Family Receptor 3 (FZD3))

Alternative Name: FZD3 (FZD3 Products)

Synonyms: Fz-3 Protein, FZ-3 Protein, fz3 Protein, Xfz3 Protein, frz3 Protein, hfz3 Protein, frz-3 Protein, frizzled3 Protein, frizzled-3 Protein, FZD3 Protein, AU020229 Protein, D930050A07Rik Protein, Fz3 Protein, fz9 Protein, fzd3 Protein, zg09 Protein, fzd3l Protein, frizzled class receptor 3 Protein, frizzled class receptor 3 L homeolog Protein, frizzled class receptor 3a Protein, frizzled class receptor 3b Protein, FZD3 Protein, fzd3 Protein, fzd3.L Protein, Fzd3 Protein, fzd3a Protein, fzd3b Protein

Background: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Molecular Weight: The human full length FZD3 protein has a MW of 76.3kDa

UniProt: Q9NPG1

Pathways: WNT Signaling, Tube Formation