FPR2 Protein

Catalog No. ABIN7538239

Product Details

Target: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human FPR2 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Alternative Name: FPR2 (FPR2 Products)

Synonyms: ALXR Protein, FMLP-R-II Protein, FMLPX Protein, FPR2A Protein, FPRH1 Protein, FPRH2 Protein, FPRL1 Protein, HM63 Protein, LXA4R Protein, E330010I07Rik Protein, Fpr-rs2 Protein, Fprl1 Protein, ALX Protein, Fpr-rs1 Protein, Fpr-s1 Protein, LXA4-R Protein, Lxa4r Protein, FMLP-R-I Protein, FPR2 Protein, formyl peptide receptor 2 Protein, formyl peptide receptor 3 Protein, N-formyl peptide receptor 2 Protein, FPR2 Protein, Fpr2 Protein, Fpr3 Protein, LOC100444626 Protein

Background: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).[UniProtKB/Swiss-Prot Function]

Molecular Weight: The human full length FPR2 protein has a MW of 39kDa

UniProt: P25090