EGFRviii Protein (AA 25-645) (His tag)

Catalog No. ABIN7538221

Product Details

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Protein Type: Recombinant

Protein Characteristics: AA 25-645

Origin: Human

Source: Mammalian Cells

Purification tag / Conjugate: This EGFRviii protein is labelled with His tag.

Purpose: Recombinant Human EGFRVIII Protein with C-terminal 6xHis tag

Specificity: EGFRVIII (Leu25-Ser645 267aa) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Alternative Name: EGFRVIII (EGFRv3 Products)

Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Molecular Weight: predicted molecular mass of 39.5 kDa after removal of the signal peptide. The apparent molecular mass of EGFRVIII-His is 55-100 kDa due to glycosylation.

UniProt: P00533