EGFRviii Protein (AA 25-645) (His tag)
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- Target See all EGFRviii (EGFRv3) products
- EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 25-645
- Origin
- Human
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Source
- Mammalian Cells
- Purification tag / Conjugate
- This EGFRviii protein is labelled with His tag.
- Purpose
- Recombinant Human EGFRVIII Protein with C-terminal 6xHis tag
- Specificity
- EGFRVIII (Leu25-Ser645 267aa) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))
- Alternative Name
- EGFRVIII (EGFRv3 Products)
- Background
- The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
- Molecular Weight
- predicted molecular mass of 39.5 kDa after removal of the signal peptide. The apparent molecular mass of EGFRVIII-His is 55-100 kDa due to glycosylation.
- UniProt
- P00533
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