Complement Factor I Protein (CFI) (AA 19-583) (His tag)
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- Target See all Complement Factor I (CFI) Proteins
- Complement Factor I (CFI)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-583
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Origin
- Human
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Source
- Mammalian Cells
- Purification tag / Conjugate
- This Complement Factor I protein is labelled with His tag.
- Purpose
- Recombinant human CFI Protein with C-terminal 6xHis tag
- Specificity
- CFI (Lys19-Val583) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CFI Protein
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Complement Factor I (CFI) (AA 19-583) protein (His tag)
CFI Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Complement Factor I (CFI) (AA 19-118) protein (GST tag)CFI Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Complement Factor I (CFI) protein (Myc-DYKDDDDK Tag)CFI Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- Complement Factor I (CFI)
- Alternative Name
- CFI (CFI Products)
- Synonyms
- cfi Protein, MGC53615 Protein, Cfi Protein, factor I Protein, IF Protein, gb:ai721528 Protein, ahus3 Protein, c3b-ina Protein, c3bc4bi Protein, c3bina Protein, kaf Protein, CFI Protein, AHUS3 Protein, C3BINA Protein, C3b-INA Protein, FI Protein, KAF Protein, complement factor I S homeolog Protein, complement factor I L homeolog Protein, complement factor I Protein, complement component factor i Protein, cfi.S Protein, cfi.L Protein, CFI Protein, cfi Protein, Cfi Protein
- Background
- This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
- Molecular Weight
- predicted molecular mass of 64.3 kDa after removal of the signal peptide. The apparent molecular mass of CFI-His is 70-100 kDa due to glycosylation.
- UniProt
- P05156
- Pathways
- Complement System
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