CCBP2 Protein
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- Target See all CCBP2 Proteins
- CCBP2 (Chemokine Binding Protein 2 (CCBP2))
- Protein Type
- Synthetic Nanodisc
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Origin
- Human
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Source
- Mammalian Cells
- Purpose
- Human ACKR2 full length protein-synthetic nanodisc
- Characteristics
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product CCBP2 Protein
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- Comment
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- CCBP2 (Chemokine Binding Protein 2 (CCBP2))
- Alternative Name
- ACKR2 (CCBP2 Products)
- Synonyms
- CCBP2 Protein, CCR10 Protein, CCR9 Protein, CMKBR9 Protein, D6 Protein, hD6 Protein, Ccbp2 Protein, LOC733624 Protein, A130091K22Rik Protein, Cmkbr10 Protein, GPR-9-6 Protein, AI464239 Protein, Cmkbr9 Protein, atypical chemokine receptor 2 Protein, atypical chemokine receptor 2-like Protein, chemokine receptor D6 Protein, chemokine (C-C motif) receptor 9 Protein, C-C motif chemokine receptor 9 Protein, ACKR2 Protein, Ackr2 Protein, LOC100219492 Protein, LOC733624 Protein, Ccr9 Protein, CCR9 Protein
- Background
- This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members, however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
- Molecular Weight
- The human full length ACKR2 protein has a MW of 43.4kDa
- UniProt
- O00590
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