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CCBP2 Protein

CCBP2 Origin: Human Host: Mammalian Cells Synthetic Nanodisc
Catalog No. ABIN7538192
  • Target See all CCBP2 Proteins
    CCBP2 (Chemokine Binding Protein 2 (CCBP2))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 5
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    • 1
    Mammalian Cells
    Purpose
    Human ACKR2 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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    Discover our top product CCBP2 Protein
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    CCBP2 (Chemokine Binding Protein 2 (CCBP2))
    Alternative Name
    ACKR2 (CCBP2 Products)
    Synonyms
    CCBP2 Protein, CCR10 Protein, CCR9 Protein, CMKBR9 Protein, D6 Protein, hD6 Protein, Ccbp2 Protein, LOC733624 Protein, A130091K22Rik Protein, Cmkbr10 Protein, GPR-9-6 Protein, AI464239 Protein, Cmkbr9 Protein, atypical chemokine receptor 2 Protein, atypical chemokine receptor 2-like Protein, chemokine receptor D6 Protein, chemokine (C-C motif) receptor 9 Protein, C-C motif chemokine receptor 9 Protein, ACKR2 Protein, Ackr2 Protein, LOC100219492 Protein, LOC733624 Protein, Ccr9 Protein, CCR9 Protein
    Background
    This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members, however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
    Molecular Weight
    The human full length ACKR2 protein has a MW of 43.4kDa
    UniProt
    O00590
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