CCRL1 Protein

Catalog No. ABIN7538188

Product Details

Target: CCRL1 (Chemokine (C-C Motif) Receptor-Like 1 (CCRL1))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human ACKR4 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCRL1 (Chemokine (C-C Motif) Receptor-Like 1 (CCRL1))

Alternative Name: ACKR4 (CCRL1 Products)

Synonyms: CC-CKR-11 Protein, CCBP2 Protein, CCR-11 Protein, CCR10 Protein, CCR11 Protein, CCRL1 Protein, CCX CKR Protein, CCX-CKR Protein, CKR-11 Protein, PPR1 Protein, VSHK1 Protein, A630091E18Rik Protein, CCX-CKR1 Protein, Ccrl1 Protein, Cmkbrl1 Protein, atypical chemokine receptor 4 Protein, chemokine (C-C motif) receptor-like 1 Protein, Chemokine receptor-like 1 Protein, chemerin chemokine-like receptor 1 Protein, ACKR4 Protein, Ackr4 Protein, CCRL1 Protein, cml1 Protein, CMKLR1 Protein

Background: The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

Molecular Weight: The human full length ACKR4 protein has a MW of 39.9kDa

UniProt: Q9NPB9