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CCR4 Protein

CCR4 Origin: Human Host: Mammalian Cells MSP Nanodisc
Catalog No. ABIN7538185
  • Target See all CCR4 Proteins
    CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))
    Protein Type
    MSP Nanodisc
    Origin
    • 8
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 4
    • 2
    • 2
    • 1
    Mammalian Cells
    Purpose
    Human CCR4 full length protein membrane nanoparticles (MNPs)
    Characteristics
    Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. Our optimized MNPs platform for the full-length membrane protein production uses membrane coating technology and a HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins.
    Top Product
    Discover our top product CCR4 Protein
  • Comment

    Advantages of Membrane Nanoparticles (MNPs):

    • High display density of target membrane proteins
    • Native structure and orientation of transmembrane protein
    • soluble in aqueous solutions for routine biochemical analysis
    • Detergent-free purification process
    • Strong immunogenicity
    • Works for MPs that can´t be produced via VLPs and EXos
    Limitations of Membrane Nanoparticles (MNPs):
    • Lack of accurate quantification of the target membrane proteins.
    • Need to develop special SPR assayx.
    • Cell membranes contain housekeeping proteins that can result in immune response dilution.
    • Some membrane proteins can´t be enriched on membrane.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))
    Alternative Name
    CCR4 (CCR4 Products)
    Synonyms
    CC-CKR-4 Protein, CD194 Protein, CKR4 Protein, CMKBR4 Protein, ChemR13 Protein, HGCN:14099 Protein, K5-5 Protein, Ccr4 Protein, C-C CKR-4 Protein, CHEMR1 Protein, Cmkbr4 Protein, LESTR Protein, Sdf1r Protein, C-C motif chemokine receptor 4 Protein, chemokine (C-C motif) receptor 4 Protein, CCR4 Protein, Ccr4 Protein
    Background
    The protein belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
    Molecular Weight
    The human full length CCR4 Protein has a MW of 41.4 kDa
    UniProt
    P51679
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