CCR2 Protein (AA 1-55) (Fc Tag)

Catalog No. ABIN7538184

Product Details

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Protein Type: Recombinant

Protein Characteristics: AA 1-55

Origin: Mouse

Source: Mammalian Cells

Purification tag / Conjugate: This CCR2 protein is labelled with Fc Tag.

Purpose: Recombinant mouse CCR2 protein with C-terminal human Fc tag

Specificity: Mouse CCR2 (Met1-Ala55) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Alternative Name: CCR2 (CCR2 Products)

Synonyms: CC-CKR-2 Protein, CCR-2 Protein, CCR2A Protein, CCR2B Protein, CD192 Protein, CKR2 Protein, CKR2A Protein, CKR2B Protein, CMKBR2 Protein, MCP-1-R Protein, ACKR5 Protein, CKRX Protein, CRAM Protein, CRAM-A Protein, CRAM-B Protein, HCR Protein, Cc-ckr-2 Protein, Ccr2a Protein, Ccr2b Protein, Ckr2 Protein, Ckr2a Protein, Ckr2b Protein, Cmkbr2 Protein, mJe-r Protein, C-C motif chemokine receptor 2 Protein, C-C motif chemokine receptor like 2 Protein, chemokine (C-C motif) receptor 2 Protein, CCR2 Protein, CCRL2 Protein, Ccr2 Protein, LOC484790 Protein

Background: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including leukocyte migration, positive regulation of cell migration, and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response, monocyte chemotaxis, and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease, aggressive periodontitis, coronary artery disease (multiple), glucose metabolism disease (multiple), and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Molecular Weight: predicted molecular mass of 32.3 kDa after removal of the signal peptide. The apparent molecular mass of mCCR2-hFc is 35-55 kDa due to glycosylation.

UniProt: P51683

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process