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CCR10 Protein

CCR10 Origin: Human Host: Mammalian Cells Synthetic Nanodisc
Catalog No. ABIN7538183
  • Target See all CCR10 Proteins
    CCR10 (Chemokine (C-C Motif) Receptor 10 (CCR10))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 4
    • 3
    Human
    Source
    • 3
    • 2
    • 2
    Mammalian Cells
    Purpose
    Human CCR10 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product CCR10 Protein
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    CCR10 (Chemokine (C-C Motif) Receptor 10 (CCR10))
    Alternative Name
    CCR10 (CCR10 Products)
    Synonyms
    GPR2 Protein, Cmkbr9 Protein, Gpr2 Protein, zgc:91924 Protein, CCR10 Protein, C-C motif chemokine receptor 10 Protein, chemokine (C-C motif) receptor 10 Protein, CCR10 Protein, Ccr10 Protein, ccr10 Protein
    Background
    Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues, the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27, MIM 604833), CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
    Molecular Weight
    The human full length CCR10 protein has a MW of 38.4kDa
    UniProt
    P46092
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