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Caveolin-1 Protein

CAV1 Origin: Human Host: Mammalian Cells Synthetic Nanodisc
Catalog No. ABIN7538162
  • Target See all Caveolin-1 (CAV1) Proteins
    Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
    Protein Type
    Synthetic Nanodisc
    Origin
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 22
    • 20
    • 1
    • 1
    Mammalian Cells
    Purpose
    Human CAV1 full length protein-synthetic nanodisc
    Characteristics
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product CAV1 Protein
  • Comment

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Expiry Date
    12 months
  • Target
    Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
    Alternative Name
    CAV1 (CAV1 Products)
    Synonyms
    fc07c04 Protein, wu:fc07c04 Protein, Cav-1 Protein, bscl3 Protein, cav1 Protein, cav1a Protein, cgl3 Protein, vip21 Protein, cav1b Protein, caveolin-1 Protein, cav Protein, mstp085 Protein, Caveolin-1 Protein, CAV1 Protein, cav-1 Protein, Cav Protein, caveolin 1 Protein, BSCL3 Protein, CGL3 Protein, MSTP085 Protein, PPH3 Protein, VIP21 Protein, caveolin 1 Protein, caveolin 1 L homeolog Protein, caveolin 1 S homeolog Protein, caveolin 1, caveolae protein Protein, caveolin 1, caveolae protein, 22kDa Protein, Caveolin Protein, cav1 Protein, cav1.L Protein, cav1.S Protein, CAV1 Protein, Cav1 Protein, cav-1 Protein
    Background
    The scaffolding protein is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
    Molecular Weight
    The human full length CAV1 protein has a MW of 20.3 kDa
    UniProt
    Q03135
    Pathways
    Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals
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