BRS3 Protein

Catalog No. ABIN7538145

Product Details

Target: BRS3 (Bombesin-Like Receptor 3 (BRS3))

Protein Type: Synthetic Nanodisc

Origin: Human

Source: Mammalian Cells

Purpose: Human BRS3 full length protein-synthetic nanodisc

Characteristics: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Application Details

Comment:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: BRS3 (Bombesin-Like Receptor 3 (BRS3))

Alternative Name: BRS3 (BRS3 Products)

Synonyms: BRS-3 Protein, BRS3 Protein, bombesin receptor subtype 3 Protein, bombesin-like receptor 3 Protein, bombesin receptor subtype-3 Protein, BRS3 Protein, Brs3 Protein, CpipJ_CPIJ017637 Protein, CpipJ_CPIJ017639 Protein, CpipJ_CPIJ017638 Protein

Background: The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

Molecular Weight: The human full length BRS3 protein has a MW of 44.4kDa

UniProt: P32247

Pathways: Feeding Behaviour