AXL Protein (AA 19-443) (His tag)

Catalog No. ABIN7538141

Product Details

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Protein Type: Recombinant

Protein Characteristics: AA 19-443

Origin: Mouse

Source: Mammalian Cells

Purification tag / Conjugate: This AXL protein is labelled with His tag.

Purpose: Recombinant mouse AXL protein with C-terminal 10xHis tag

Specificity: Mouse AXL (Ala19-Pro443) 10xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: AXL (AXL Receptor tyrosine Kinase (AXL))

Alternative Name: AXL (AXL Products)

Synonyms: JTK11 Protein, UFO Protein, AI323647 Protein, Ark Protein, Tyro7 Protein, Ufo Protein, AXL receptor tyrosine kinase Protein, Axl receptor tyrosine kinase Protein, AXL Protein, Axl Protein

Background: Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity, phosphatidylserine binding activity, and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development, myeloid cell homeostasis, and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton, cell surface, and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, respiratory system, and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Molecular Weight: predicted molecular mass of 47.8 kDa after removal of the signal peptide. The apparent molecular mass of mAXL-His is 55-70 kDa due to glycosylation.

UniProt: Q00993

Pathways: RTK Signaling, Cellular Response to Molecule of Bacterial Origin