APOH Protein (AA 20-345) (His tag)

Catalog No. ABIN7538136

Product Details

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Protein Type: Recombinant

Protein Characteristics: AA 20-345

Origin: Human

Source: Mammalian Cells

Purification tag / Conjugate: This APOH protein is labelled with His tag.

Purpose: Recombinant human APOH Protein with C-terminal 6xHis tag

Specificity: APOH (Gly20-Cys345) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Alternative Name: APOH (APOH Products)

Synonyms: B2G1 Protein, B2GP1 Protein, BG Protein, BETA2 Protein, BHF-1 Protein, MODY6 Protein, NEUROD Protein, bHLHa3 Protein, apoh Protein, APOH Protein, B2GPI Protein, beta-2-GPI Protein, beta2-GPI Protein, LOC100227913 Protein, apolipoprotein H Protein, neuronal differentiation 1 Protein, APOH Protein, NEUROD1 Protein, apoh Protein, Apoh Protein

Background: Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]

Molecular Weight: predicted molecular mass of 37.1 kDa after removal of the signal peptide. The apparent molecular mass of APOH-His is 35-70 kDa due to glycosylation.

UniProt: P02749