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TEK Protein

TEK Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 97 % by SDS-PAGE. Active
Catalog No. ABIN7520536
  • Target See all TEK Proteins
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 17
    • 8
    • 3
    • 2
    • 2
    • 1
    Human
    Source
    • 10
    • 10
    • 4
    • 4
    • 1
    • 1
    Baculovirus infected Insect Cells
    Purpose
    Active Recombinant Human TIE2/TEK/CD202b Protein
    Sequence
    KNNPDPTIYP VLDWNDIKFQ DVIGEGNFGQ VLKARIKKDG LRMDAAIKRM KEYASKDDHR DFAGELEVLC KLGHHPNIIN LLGACEHRGY LYLAIEYAPH GNLLDFLRKS RVLETDPAFA IANSTASTLS SQQLLHFAAD VARGMDYLSQ KQFIHRDLAA RNILVGENYV AKIADFGLSR GQEVYVKKTM GRLPVRWMAI ESLNYSVYTT NSDVWSYGVL LWEIVSLGGT PYCGMTCAEL YEKLPQGYRL EKPLNCDDEV YDLMRQCWRE KPYERPSFAQ ILVSLNRMLE ERKTYVNTTL YEKFTYAGID CSAEEAA
    Specificity
    Lys808-Ala1124
    Purity
    > 97 % by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    < 1.0 EU/μg of the protein by LAL method.
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA. Immobilized Human TEK Protein at 2 μg/mL (100 μL/well) can bind ANG2 with a linear range of 39-7090 ng/mL.
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  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
    Buffer
    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store the lyophilized protein at -20°C to -80 °C for long term.
    After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
  • Target
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    Alternative Name
    TIE2/TEK/CD202b (TEK Products)
    Synonyms
    TEK Protein, DKFZp469E064 Protein, AA517024 Protein, Cd202b Protein, Hyk Protein, Tie2 Protein, tie-2 Protein, CD202B Protein, TIE-2 Protein, TIE2 Protein, VMCM Protein, VMCM1 Protein, Tie-2 Protein, tie2 Protein, TEK receptor tyrosine kinase Protein, angiopoietin-1 receptor Protein, TEK tyrosine kinase, endothelial Protein, TEK Protein, LOC100408334 Protein, tek Protein, Tek Protein
    Background

    Description: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts.

    Name: TEK,CD202B,GLC3E,TIE-2,TIE2,VMCM,VMCM1,Tie2

    Gene ID
    7010
    UniProt
    Q02763
    Pathways
    RTK Signaling, Growth Factor Binding
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