TEK Protein
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- Target See all TEK Proteins
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purpose
- Active Recombinant Human TIE2/TEK/CD202b Protein
- Sequence
- KNNPDPTIYP VLDWNDIKFQ DVIGEGNFGQ VLKARIKKDG LRMDAAIKRM KEYASKDDHR DFAGELEVLC KLGHHPNIIN LLGACEHRGY LYLAIEYAPH GNLLDFLRKS RVLETDPAFA IANSTASTLS SQQLLHFAAD VARGMDYLSQ KQFIHRDLAA RNILVGENYV AKIADFGLSR GQEVYVKKTM GRLPVRWMAI ESLNYSVYTT NSDVWSYGVL LWEIVSLGGT PYCGMTCAEL YEKLPQGYRL EKPLNCDDEV YDLMRQCWRE KPYERPSFAQ ILVSLNRMLE ERKTYVNTTL YEKFTYAGID CSAEEAA
- Specificity
- Lys808-Ala1124
- Purity
- > 97 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 1.0 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human TEK Protein at 2 μg/mL (100 μL/well) can bind ANG2 with a linear range of 39-7090 ng/mL.
- Top Product
- Discover our top product TEK Protein
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TEK Tyrosine Kinase, Endothelial (TEK) (AA 23-748) (Active) protein (Fc Tag)
TEK Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) protein (GST tag)TEK Origin: Human Host: Wheat germ Recombinant WB, AP, AA, ELISA
TEK Tyrosine Kinase, Endothelial (TEK) (AA 770-1122) (Active) protein (GST tag,His tag)TEK Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 91 % as determined by SDS-PAGE Active
TEK Tyrosine Kinase, Endothelial (TEK) (Active) protein (His tag)TEK Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
TEK Tyrosine Kinase, Endothelial (TEK) (Active) protein (Fc Tag)TEK Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Buffer
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- Storage
- -20 °C,-80 °C
- Storage Comment
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Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
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- Target
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
- Alternative Name
- TIE2/TEK/CD202b (TEK Products)
- Synonyms
- TEK Protein, DKFZp469E064 Protein, AA517024 Protein, Cd202b Protein, Hyk Protein, Tie2 Protein, tie-2 Protein, CD202B Protein, TIE-2 Protein, TIE2 Protein, VMCM Protein, VMCM1 Protein, Tie-2 Protein, tie2 Protein, TEK receptor tyrosine kinase Protein, angiopoietin-1 receptor Protein, TEK tyrosine kinase, endothelial Protein, TEK Protein, LOC100408334 Protein, tek Protein, Tek Protein
- Background
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Description: Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts.
Name: TEK,CD202B,GLC3E,TIE-2,TIE2,VMCM,VMCM1,Tie2
- Gene ID
- 7010
- UniProt
- Q02763
- Pathways
- RTK Signaling, Growth Factor Binding
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