Sclerostin Protein (SOST) (His tag)

Catalog No. ABIN7535941

Product Details

Target: Sclerostin (SOST)

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This Sclerostin protein is labelled with His tag.

Purpose: Recombinant Rat Sclerostin/SOST Protein

Sequence: FKNDATEIIP GLREYPEPPQ ELENNQTMNR AENGGRPPHH PYDTKDVSEY SCRELHYTRF VTDGPCRSAK PVTELVCSGQ CGPARLLPNA IGRVKWWRPN GPDFRCIPDR YRAQRVQLLC PGGAAPRSRK VRLVASCKCK RLTRFHNQSE LKDFGPETAR PQKGRKPRPR ARGAKANQAE LENAY

Specificity: Phe29-Tyr213

Purity: > 95 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: <0.1EU/μg

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Target Details

Target: Sclerostin (SOST)

Alternative Name: Sclerostin/SOST (SOST Products)

Synonyms: LOC100313724 Protein, CDD Protein, VBCH Protein, 5430411E23Rik Protein, sclerostin Protein, LOC100313724 Protein, SOST Protein, Sost Protein

Background:

Description: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Name: sclerostin,SOST,VBCH,SOST

Gene ID: 80722

UniProt: Q99P67