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s100a4 Protein

S100A4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE.
Catalog No. ABIN7535876
  • Target See all s100a4 (S100A4) Proteins
    s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))
    Protein Type
    Recombinant
    Origin
    • 11
    • 5
    • 3
    • 3
    • 1
    Human
    Source
    • 13
    • 5
    • 3
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human S100-A4 Protein
    Sequence
    ACPLEKALDV MVSTFHKYSG KEGDKFKLNK SELKELLTRE LPSFLGKRTD EAAFQKLMSN LDSNRDNEVD FQEYCVFLSC IAMMCNEFFE GFPDKQPRKK
    Specificity
    Ala2-Lys101
    Purity
    > 95 % by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    <0.1EU/μg
    Top Product
    Discover our top product S100A4 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
    Buffer
    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • Target
    s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))
    Alternative Name
    S100-A4 (S100A4 Products)
    Synonyms
    18A2 Protein, 42A Protein, CAPL Protein, FSP1 Protein, MTS1 Protein, P9KA Protein, PEL98 Protein, 42a Protein, Capl Protein, FSp1 Protein, Mts1 Protein, PeL98 Protein, metastasin Protein, pk9a Protein, S100A4 Protein, P9ka Protein, RNP9KA Protein, S100 calcium binding protein A4 Protein, S100 calcium-binding protein A4 Protein, S100A4 Protein, S100a4 Protein
    Background

    Description: S100A4 belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

    Name: 18A2,42A,CAPL,FSP1,MTS1,P9KA,PEL98,S100A4, 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98, protein S100-A4

    Gene ID
    6275
    UniProt
    P26447
    Pathways
    S100 Proteins
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