Prolactin Receptor Protein (PRLR) (His tag)

Catalog No. ABIN7534027

Product Details

Target: Prolactin Receptor (PRLR)

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Prolactin Receptor protein is labelled with His tag.

Purpose: Active Recombinant Human Prolactin receptor/PRL-R Protein

Sequence: QLPPGKPEIF KCRSPNKETF TCWWRPGTDG GLPTNYSLTY HREGETLMHE CPDYITGGPN SCHFGKQYTS MWRTYIMMVN ATNQMGSSFS DELYVDVTYI VQPDPPLELA VEVKQPEDRK PYLWIKWSPP TLIDLKTGWF TLLYEIRLKP EKAAEWEIHF AGQQTEFKIL SLHPGQKYLV QVRCKPDHGY WSAWSPATFI QIPSDFTMND

Specificity: Gln25-Asp234

Purity: > 97 % by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human PRLR/Prolactin Receptor at 1 μg/mL (100 μL/well) can bind Prolactin Receptor Rabbit mAb with a linear range of 0.67-3.45 ng/mL.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Storage: -20 °C,-80 °C

Storage Comment: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Target Details

Target: Prolactin Receptor (PRLR)

Alternative Name: Prolactin receptor/PRL-R (PRLR Products)

Synonyms: hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein

Background:

Description: The protenin is a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.

Name: HPRL, MFAB, hPRLrI,PRLR,MFAB,hPRLrI

Gene ID: 5618

UniProt: P16471

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus