FGF23 Protein (His tag)
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- Target See all FGF23 Proteins
- FGF23 (Fibroblast Growth Factor 23 (FGF23))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FGF23 protein is labelled with His tag.
- Purpose
- Recombinant human FGF-23/Fibroblast growth factor 23 Protein
- Sequence
- YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI
- Specificity
- Tyr25-Ile251
- Purity
- > 97 % by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- < 0.1EU/μg
- Top Product
- Discover our top product FGF23 Protein
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Fibroblast Growth Factor 23 (FGF23) (AA 25-251) (Active) protein (His tag)
FGF23 Origin: Mouse Host: Escherichia coli (E. coli) > 90 % AcA, CC Active
Fibroblast Growth Factor 23 (FGF23) (AA 25-251) protein (His tag)FGF23 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fibroblast Growth Factor 23 (FGF23) (AA 1-251) protein (GST tag)FGF23 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor 23 (FGF23) (AA 25-251), (full length) protein (His tag)FGF23 Origin: Rat Host: Yeast Recombinant > 90 % ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- Concentration
- 0.3 mg/mL
- Buffer
- Lyophilized from a 0.22 μm filtered solution of 20 mM MOPS,150 mM NaCl,5 mM EDTA,2 mM DTT, pH 7.4
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- Target
- FGF23 (Fibroblast Growth Factor 23 (FGF23))
- Alternative Name
- FGF-23/Fibroblast growth factor 23 (FGF23 Products)
- Synonyms
- FGF23 Protein, ADHR Protein, FGFN Protein, HPDR2 Protein, HYPF Protein, PHPTC Protein, fibroblast growth factor 23 Protein, fgf23 Protein, FGF23 Protein, Fgf23 Protein
- Background
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Description: Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho. FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. FGF23 and phosphate have been revealed to be factors relevant in cancer. FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.
Name: ADHR, FGFN, HYPF, HFTC2, HPDR2, PHPTC
- Gene ID
- 8074
- UniProt
- Q9GZV9
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion
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