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CD8 alpha Protein (Fc Tag)

CD8A Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % by SDS-PAGE.
Catalog No. ABIN7535717
  • Target See all CD8 alpha (CD8A) Proteins
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Protein Type
    Recombinant
    Origin
    • 12
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Mouse
    Source
    • 12
    • 7
    • 5
    • 3
    HEK-293 Cells
    Purification tag / Conjugate
    This CD8 alpha protein is labelled with Fc Tag.
    Purpose
    Recombinant Mouse CD8a Protein
    Sequence
    KPQAPELRIF PKKMDAELGQ KVDLVCEVLG SVSQGCSWLF QNSSSKLPQP TFVVYMASSH NKITWDEKLN SSKLFSAMRD TNNKYVLTLN KFSKENEGYY FCSVISNSVM YFSSVVPVLQ KVNSTTTKPV LRTPSPVHPT GTSQPQRPED CRPRGSVKGT GLDFACDIY
    Specificity
    Lys28-Tyr196
    Purity
    > 95 % by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    <0.1EU/μg
    Top Product
    Discover our top product CD8A Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
    Buffer
    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • Target
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Alternative Name
    CD8a (CD8A Products)
    Synonyms
    cd8 Protein, LOC100136450 Protein, BB154331 Protein, Ly-2 Protein, Ly-35 Protein, Ly-B Protein, Lyt-2 Protein, zgc:136643 Protein, CD8 Protein, Leu2 Protein, MAL Protein, p32 Protein, RHACD8-4 Protein, CD8a molecule Protein, uncharacterized LOC100125537 Protein, CD8 alpha Protein, CD8 antigen, alpha chain Protein, T-cell surface glycoprotein CD8 alpha chain Protein, Cd8a Protein, LOC100125537 Protein, LOC100136450 Protein, CD8A Protein, cd8a Protein, LOC100126556 Protein
    Background

    Description: T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

    Name: Ly-2, Ly-B, Ly-35, Lyt-2,CD8A

    Gene ID
    12525
    UniProt
    P01731
    Pathways
    TCR Signaling
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