ICAM1 Protein (AA 1-493) (Fc Tag)
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- Target See all ICAM1 Proteins
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-493
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ICAM1 protein is labelled with Fc Tag.
- Sequence
- Met1-Thr493
- Characteristics
- A DNA sequence encoding the Rat ICAM-1 protein (Q00238) (Met1-Thr493) was expressed with a C-Fc.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product ICAM1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
- Alternative Name
- ICAM-1 (ICAM1 Products)
- Synonyms
- BB2 Protein, CD54 Protein, P3.58 Protein, Icam-1 Protein, Ly-47 Protein, MALA-2 Protein, ICAM Protein, ICAM-1 Protein, ICAM1 Protein, intercellular adhesion molecule 1 Protein, intercellular adhesion molecule-1 Protein, ICAM1 Protein, Icam1 Protein, ICAM-1 Protein
- Background
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Abbreviation: ICAM-1,CD54
Target Synonym: CD54,ICAM
Background: Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.
- Molecular Weight
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Calculated MW: 89.12 kDa
Observed MW: 90 kDa
- UniProt
- Q00238
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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