CD163 Protein (CD163) (AA 693-939) (His tag)
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- Target See all CD163 Proteins
- CD163
- Protein Type
- Recombinant
- Protein Characteristics
- AA 693-939
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD163 protein is labelled with His tag.
- Sequence
- Pro693-Asp939
- Characteristics
- A DNA sequence encoding the Rat CD163 protein (A0A0G2JVY2) (Pro693-Asp939) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CD163 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- CD163
- Alternative Name
- CD163 (CD163 Products)
- Synonyms
- DMBT1 Protein, CD163 Protein, CD163v2 Protein, CD163v3 Protein, M130 Protein, MM130 Protein, deleted in malignant brain tumors 1 protein-like Protein, CD163 molecule Protein, CD163 antigen Protein, LOC426820 Protein, CD163 Protein, Cd163 Protein
- Background
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Abbreviation: CD163
Target Synonym: CD163 Molecule,Cd163
Background: CD163, also known as M130 and p155, is a transmembrane scavenger receptor that is expressed on monocytes and macrophages and is inducible by immunosuppressant glucocorticoids and IL-10. A soluble form is shed from the cell surface by TACE or neutrophil elastase mediated cleavage in response to oxidative stress, Prostaglandin F2a stimulation, or the activation of Fc gamma receptors, TLR1, 2, 5, or 6. CD163 mediates monocyte binding to bacteria, leading to the release of inflammatory cytokines. It is essential for the circulatory clearance of hemoglobin-haptoglobin (Hb-Hp) complexes as well as free hemoglobin. It can also mediate monocyte-erythroblast adhesion and promote erythroblast expansion. CD163 binds and internalizes the cytokine TWEAK, and the ratio of soluble CD163 to TWEAK in the plasma is elevated during atherosclerosis.
- Molecular Weight
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Calculated MW: 27.06 kDa
Observed MW: 45 kDa
- UniProt
- A0A0G2JVY2
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