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CD163 Protein (CD163) (AA 693-939) (His tag)

CD163 Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505775
  • Target See all CD163 Proteins
    CD163
    Protein Type
    Recombinant
    Protein Characteristics
    AA 693-939
    Origin
    • 12
    • 7
    • 1
    Rat
    Source
    • 8
    • 5
    • 4
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CD163 protein is labelled with His tag.
    Sequence
    Pro693-Asp939
    Characteristics
    A DNA sequence encoding the Rat CD163 protein (A0A0G2JVY2) (Pro693-Asp939) was expressed with a C-His.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CD163 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    12 months
  • Target
    CD163
    Alternative Name
    CD163 (CD163 Products)
    Synonyms
    DMBT1 Protein, CD163 Protein, CD163v2 Protein, CD163v3 Protein, M130 Protein, MM130 Protein, deleted in malignant brain tumors 1 protein-like Protein, CD163 molecule Protein, CD163 antigen Protein, LOC426820 Protein, CD163 Protein, Cd163 Protein
    Background

    Abbreviation: CD163

    Target Synonym: CD163 Molecule,Cd163

    Background: CD163, also known as M130 and p155, is a transmembrane scavenger receptor that is expressed on monocytes and macrophages and is inducible by immunosuppressant glucocorticoids and IL-10. A soluble form is shed from the cell surface by TACE or neutrophil elastase mediated cleavage in response to oxidative stress, Prostaglandin F2a stimulation, or the activation of Fc gamma receptors, TLR1, 2, 5, or 6. CD163 mediates monocyte binding to bacteria, leading to the release of inflammatory cytokines. It is essential for the circulatory clearance of hemoglobin-haptoglobin (Hb-Hp) complexes as well as free hemoglobin. It can also mediate monocyte-erythroblast adhesion and promote erythroblast expansion. CD163 binds and internalizes the cytokine TWEAK, and the ratio of soluble CD163 to TWEAK in the plasma is elevated during atherosclerosis.

    Molecular Weight

    Calculated MW: 27.06 kDa

    Observed MW: 45 kDa

    UniProt
    A0A0G2JVY2
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