COL4A1 Protein (AA 1441-1669) (His tag)
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- Target See all COL4A1 Proteins
- COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1441-1669
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This COL4A1 protein is labelled with His tag.
- Sequence
- Ser1441-Thr1669
- Characteristics
- A DNA sequence encoding the Mouse COL4 protein (P02463) (Ser1441-Thr1669) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product COL4A1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))
- Alternative Name
- COL4A1 (COL4A1 Products)
- Synonyms
- col4a1 Protein, wu:fc02g11 Protein, HANAC Protein, ICH Protein, POREN1 Protein, arresten Protein, Bru Protein, Col4a-1 Protein, Del(8)44H Protein, Raw Protein, Svc Protein, collagen, type IV, alpha 5 (Alport syndrome) Protein, collagen type IV alpha 1 chain Protein, collagen, type IV, alpha 1 Protein, col4a5 Protein, COL4A1 Protein, Col4a1 Protein
- Background
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Abbreviation: COL4
Target Synonym: Collagen alpha-1(IV) chain,Arresten,Col4a1
Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.
- Molecular Weight
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Calculated MW: 25.08 kDa
Observed MW: 30 kDa
- UniProt
- P02463
- Pathways
- Skeletal Muscle Fiber Development, Growth Factor Binding
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