2B4 Protein (AA 1-221) (His tag)
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- Target See all 2B4 (CD244) Proteins
- 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-221
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This 2B4 protein is labelled with His tag.
- Sequence
- Met1-Arg221
- Characteristics
- A DNA sequence encoding the Human 2B4 protein (Q9BZW8) (Met1-Arg221) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CD244 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
- Alternative Name
- 2B4 (CD244 Products)
- Synonyms
- CD244 Protein, 2B4 Protein, NAIL Protein, NKR2B4 Protein, Nmrk Protein, SLAMF4 Protein, C9.1 Protein, F730046O15Rik Protein, Ly90 Protein, CD244 molecule Protein, CD244 natural killer cell receptor 2B4 Protein, CD244 Protein, Cd244 Protein
- Background
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Abbreviation: 2B4;CD244
Target Synonym: Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NAIL;NKR2B4;h2B4;SLAM family member 4;SLAMF4;CD244;2B4
Background: The CD244 antigen; also known as 2B4; is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production; which is expressed on all NK cells; a subpopulation of T cells; monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor; human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity; induce secretion of IFN-γ and matrix metalloproteinases (MMPs); as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2; CD48; CD58; CD84; Ly-9; and SLAM; 2B4 (CD244) is expressed on all human NK cells; a subpopulation of T cells; basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity; induces secretion of IFN-gamma and matrix metalloproteinases; and NK cell invasiveness.
- Molecular Weight
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Calculated MW: 24.2 kDa
Observed MW: 40 kDa
- UniProt
- Q9BZW8
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