BTN3A1 Protein (AA 1-254) (His tag)
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- Target See all BTN3A1 Proteins
- BTN3A1 (Butyrophilin, Subfamily 3, Member A1 (BTN3A1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-254
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BTN3A1 protein is labelled with His tag.
- Sequence
- Met1-Gly254
- Characteristics
- A DNA sequence encoding the Human BTN3A1,CD277 protein (O00481) (Met1-Gly254) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product BTN3A1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- BTN3A1 (Butyrophilin, Subfamily 3, Member A1 (BTN3A1))
- Alternative Name
- BTN3A1 (BTN3A1 Products)
- Synonyms
- BT3.1 Protein, BTF5 Protein, CD277 Protein, BTN3A1 Protein, butyrophilin subfamily 3 member A1 Protein, BTN3A1 Protein, LOC100447925 Protein
- Background
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Abbreviation: BTN3A1,CD277
Target Synonym: Butyrophilin subfamily 3 member A1,CD277,BTN3A1,BTF5
Background: Butyrophilin Subfamily 3 Member A1 (BTN3A1/CD277) is a type I transmembrane glycoprotein member of the Ig superfamily. It is expressed on a wide variety of immune cells. Similar to BTN3A2 and BTN3A3, BTN3A1 is composed of an extracellular N-terminal IgV and a membraneproximal IgC domain followed by a transmembrane domain and a cytoplasmic tail. These Ig domains are also found in B7 family costimulatory molecules, suggesting structural and functional similarities between the two protein families. BTN3A1 acts as a critical protein for the activation of Vγ9Vδ2 T cells following detection of distressed cells. The anti-tumor responses of Vγ9Vδ2 T cells may be enhanced with agonistic anti-BTNA3 antibodies.
- Molecular Weight
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Calculated MW: 27.83 kDa
Observed MW: 30 kDa
- UniProt
- O00481
- Pathways
- Activated T Cell Proliferation
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