LILRB2 Protein (AA 1-461) (His tag)
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- Target See all LILRB2 Proteins
- LILRB2 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-461
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This LILRB2 protein is labelled with His tag.
- Sequence
- Met1-Val461
- Characteristics
- A DNA sequence encoding the Human ILT4(LILRB2) protein (Q8N423) (Met1-Val461) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product LILRB2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- LILRB2 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2))
- Alternative Name
- ILT4 (LILRB2 Products)
- Synonyms
- CD85D Protein, ILT-4 Protein, ILT4 Protein, LIR-2 Protein, LIR2 Protein, MIR-10 Protein, MIR10 Protein, leukocyte immunoglobulin-like receptor subfamily A member 3 Protein, leukocyte immunoglobulin like receptor B2 Protein, LOC100433990 Protein, LILRB2 Protein
- Background
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Abbreviation: ILT4,LILRB2
Target Synonym: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2,LIR-2,Leukocyte Immunoglobulin-Like Receptor 2,CD85 Antigen-Like Family Member D,Immunoglobulin-Like Transcript 4,ILT-4,Monocyte/Macrophage Immunoglobulin-Like Receptor 10,MIR-10,CD85d,L
Background: Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
- Molecular Weight
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Calculated MW: 50.6 kDa
Observed MW: 75 kDa
- UniProt
- Q8N423
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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