TIMP1 Protein (AA 1-207) (His tag)

Catalog No. ABIN7505680

Product Details

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Protein Type: Recombinant

Protein Characteristics: AA 1-207

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TIMP1 protein is labelled with His tag.

Sequence: Met1-Ala207

Characteristics: A DNA sequence encoding the Human TIMP-1 protein (P01033) (1-207) was expressed with a C-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Alternative Name: TIMP-1 (TIMP1 Products)

Synonyms: TIMP-1 Protein, TIMP1 Protein, DKFZp468A0912 Protein, CLGI Protein, EPA Protein, EPO Protein, HCI Protein, TIMP Protein, Timp Protein, Clgi Protein, TIMP metallopeptidase inhibitor 1 Protein, tissue inhibitor of metalloproteinase 1 Protein, TIMP1 Protein, Timp1 Protein

Background:

Abbreviation: TIMP-1

Target Synonym: Metalloproteinase Inhibitor 1,Erythroid-Potentiating Activity,EPA,Fibroblast collagenase Inhibitor,Collagenase Inhibitor,Tissue Inhibitor of Metalloproteinases 1,TIMP-1,TIMP1,CLGI,TIMP,CLGI,EPA,EPO,HCI

Background: Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) is a member of TIMP family. The homologous proteins of TIMPs regulate the activity of matrix metalloproteinases (MMPs), including inhibition of active MMPs, proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Timp-1 complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. It also mediates erythropoiesis in vitro, but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. It is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16, without MMP-14.

Molecular Weight:

Calculated MW: 22.66 kDa

Observed MW: 30 kDa

UniProt: P01033