SERPINA6 Protein (AA 1-405) (His tag)
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- Target See all SERPINA6 Proteins
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-405
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SERPINA6 protein is labelled with His tag.
- Sequence
- Met 1-Val 405
- Characteristics
- A DNA sequence encoding the Human CBG/SERPINA6 protein (P08185) (Met 1-Val 405) was expressed with a C-His .
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product SERPINA6 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- SERPINA6 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6))
- Alternative Name
- SerpinA6 (SERPINA6 Products)
- Synonyms
- ep45-A Protein, SERPINA6 Protein, AI265318 Protein, AV104445 Protein, Cbg Protein, CBG Protein, serpin family A member 6 Protein, serpin family A member 6 L homeolog Protein, corticosteroid-binding globulin Protein, serine (or cysteine) peptidase inhibitor, clade A, member 6 Protein, SERPINA6 Protein, serpina6.L Protein, LOC490838 Protein, Serpina6 Protein
- Background
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Abbreviation: SerpinA6,CBG
Target Synonym: Corticosteroid-Binding Globulin,CBG,Serpin A6,Transcortin,SERPINA6,CBG
Background: Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
- Molecular Weight
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Calculated MW: 44.44 kDa
Observed MW: 60 kDa
- UniProt
- P08185
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