Fetuin A Protein (AA 1-367) (His tag)
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- Target See all Fetuin A (AHSG) Proteins
- Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-367
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Fetuin A protein is labelled with His tag.
- Sequence
- Met1-Val367
- Characteristics
- A DNA sequence encoding the Human FETUA protein (P02765) (Met1-Val367) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AHSG Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))
- Alternative Name
- Fetuin-A (AHSG Products)
- Synonyms
- ahs Protein, a2hs Protein, hsga Protein, fetua Protein, wu:fb63g02 Protein, zgc:103687 Protein, AHSG Protein, MGC116429 Protein, A2HS Protein, AHS Protein, FETUA Protein, HSGA Protein, Aa2-066 Protein, pp63 Protein, alpha-2-HS-glycoprotein Protein, alpha 2-HS glycoprotein Protein, alpha-2-HS-glycoprotein 1 Protein, alpha-2-HS-glycoprotein L homeolog Protein, Cphamn1_1981 Protein, AHSG Protein, ahsg Protein, ahsg1 Protein, ahsg.L Protein, Ahsg Protein
- Background
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Abbreviation: Fetuin-A,AHSG
Target Synonym: Alpha-2-HS-Glycoprotein,Alpha-2-Z-Globulin,Ba-Alpha-2-Glycoprotein,Fetuin-A,AHSG,FETUA
Background: Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.
- Molecular Weight
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Calculated MW: 40.26 kDa
Observed MW: 58 kDa
- UniProt
- P02765
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