IGFBP7 Protein (AA 1-282) (His tag)

Catalog No. ABIN7505664

Product Details

Target: IGFBP7 (Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))

Protein Type: Recombinant

Protein Characteristics: AA 1-282

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IGFBP7 protein is labelled with His tag.

Sequence: Met1-Leu282

Characteristics: A DNA sequence encoding the Human IGFBP-7 protein (Q16270) (Met1-Leu282) was expressed with a C-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IGFBP7 (Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))

Alternative Name: IGFBP-7 (IGFBP7 Products)

Synonyms: zgc:85888 Protein, AGM Protein, FSTL2 Protein, IBP-7 Protein, IGFBP-7 Protein, IGFBP-7v Protein, IGFBPRP1 Protein, MAC25 Protein, PSF Protein, RAMSVPS Protein, TAF Protein, Fstl2 Protein, Mac25 Protein, insulin like growth factor binding protein 7 Protein, insulin-like growth factor binding protein 7 Protein, IGFBP7 Protein, igfbp7 Protein, Igfbp7 Protein

Background:

Abbreviation: IGFBP-7

Target Synonym: Insulin-like growth factor-binding protein 7,IGFBP7,IGF-binding protein 7,IGFBP-rP1,MAC25 protein,Tumor-derived adhesion factor,TAF

Background: Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94 % aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin. IGFBP7 also has IGF/insulin-independent activities. It interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, promotes cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. It modulates tumor cell growth and has also been implicated in angiogenesis.

Molecular Weight:

Calculated MW: 30.91 kDa

Observed MW: 32 kDa

UniProt: Q16270

Pathways: Growth Factor Binding