WISP1 Protein (AA 1-367) (His tag)
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- Target See all WISP1 Proteins
- WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-367
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This WISP1 protein is labelled with His tag.
- Sequence
- Met1-Asn367
- Characteristics
- A DNA sequence encoding the Human WISP1 protein (O95388) (Met1-Asn367) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product WISP1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
- Alternative Name
- WISP1 (WISP1 Products)
- Synonyms
- CCN4 Protein, WISP1c Protein, WISP1i Protein, WISP1tc Protein, WISP-1 Protein, WISP1 Protein, si:ch211-38f10.2 Protein, AW146261 Protein, Elm1 Protein, zgc:172276 Protein, WNT1 inducible signaling pathway protein 1 Protein, WNT1 inducible signaling pathway protein 1a Protein, WNT1-inducible-signaling pathway protein 1-like Protein, WNT1 inducible signaling pathway protein 1b Protein, WISP1 Protein, wisp1a Protein, Wisp1 Protein, LOC100627044 Protein, wisp1b Protein
- Background
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Abbreviation: WISP1
Target Synonym: CCN family member 4,WNT1-inducible-signaling pathway protein 1,WISP-1,Wnt-1-induced secreted protein,WISP1,CCN4
Background: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.
- Molecular Weight
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Calculated MW: 40.26 kDa
Observed MW: 60 kDa
- UniProt
- O95388
- Pathways
- WNT Signaling, Growth Factor Binding
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