FBLN2 Protein (AA 1-1184) (His tag)
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- Target See all FBLN2 Proteins
- FBLN2 (Fibulin 2 (FBLN2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-1184
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FBLN2 protein is labelled with His tag.
- Sequence
- Met1-Leu1184
- Characteristics
- A DNA sequence encoding the Human FBLN2 protein (P98095) (Met1-Leu1184) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product FBLN2 Protein
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Fibulin 2 (FBLN2) (AA 1076-1184) protein (GST tag)
FBLN2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibulin 2 (FBLN2) (AA 28-1184) protein (GST tag)FBLN2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibulin 2 (FBLN2) proteinFBLN2 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- FBLN2 (Fibulin 2 (FBLN2))
- Alternative Name
- FBLN2 (FBLN2 Products)
- Synonyms
- 5730577E14Rik Protein, fibulin 2 Protein, fibulin-2 Protein, FBLN2 Protein, fbln2 Protein, LOC100440421 Protein, Fbln2 Protein
- Background
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Abbreviation: FBLN2
Target Synonym: Fibulin-2 (FIBL-2),FBLN2
Background: Fibulin 2 is the second largest member of the seven-member fibulin family of extracellular membrane (ECM) glycoproteins. Fibulin-2 consists of 1184 amino acids (aa) with a predicted molecular weight of ~125 kDa. The overall structure is common to fibulins: 3 Anaphylatoxin (AT)-like domains, 11 Epidermal Growth Factor (EGF)?like domains, and a Fibulin-type carboxy-terminal (FC) domain. Fibulin 2 is considered a Class I fibulin because the 400-residue N-terminus is divided into the Na and Nb sections, with the Na section containing 150-residues and 12 cysteines while the remaining Nb section is cysteine-free. The protein is known to form disulfide-linked homodimers, but it can also be secreted as an oligomer. Fibulin 2 is highly conserved across species, with the human protein sharing 82 % amino acid identity compared to both mouse and rat. Fibulin 2 is considered a multifunctional binding protein due to its association with numerous ECM components, but its specific interactions have yet to be determined. Fibulin 2 is localized at the interface between microfibrils and the elastin core and its known interactions include nidogen-1, perlecan, laminin, aggrecan, endostatins, versican, collagen, and tropoelastin. It is down-regulated in numerous forms of cancer including breast, colorectal, lung, esophageal, and squamous cell carcinoma, but over-expression has been shown with solid tumors. There is also evidence that suggests that Fibulin 2 may play an indirect role in the neurogenesis of adult neural stem cells via interaction with integrins and TGF-beta 1.
- Molecular Weight
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Calculated MW: 130.13 kDa
Observed MW: 130 kDa
- UniProt
- P98095
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