Lp(a) Protein (AA 1719-2038) (His tag)
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- Target
- Lp(a) (Lipoprotein (Lp(a)))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1719-2038
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Lp(a) protein is labelled with His tag.
- Sequence
- Asp1719-Arg2038
- Characteristics
- A DNA sequence encoding the Human LP-a protein (P08519) (Asp1719-Arg2038) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Lp(a) (Lipoprotein (Lp(a)))
- Alternative Name
- Lipoprotein A
- Background
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Abbreviation: Apolipoprotein,Lp
Target Synonym: APOA,Apolipoprotein(a),Apo(a),Lp(a),LPA,Lp(a)
Background: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.
- Molecular Weight
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Calculated MW: 35.09 kDa
Observed MW: 35 kDa
- UniProt
- P08519
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