TFPI2 Protein (AA 1-235) (His tag)
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- Target See all TFPI2 Proteins
- TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-235
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TFPI2 protein is labelled with His tag.
- Sequence
- Met1-Phe235
- Characteristics
- A DNA sequence encoding the Human TFPI2 protein (P48307) (Met1-Phe235) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product TFPI2 Protein
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Tissue Factor Pathway Inhibitor 2 (TFPI2) protein (His tag)
TFPI2 Origin: Human Host: Tobacco (Nicotiana benthamiana) Recombinant > 97 % by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. Func
Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 23-213) protein (His tag)TFPI2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tissue Factor Pathway Inhibitor 2 (TFPI2) (AA 1-235) protein (GST tag)TFPI2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))
- Alternative Name
- TFPI2 (TFPI2 Products)
- Synonyms
- MGC68843 Protein, TFPI2 Protein, MGC108301 Protein, si:ch211-262k23.2 Protein, tfpi2 Protein, PP5 Protein, REF1 Protein, TFPI-2 Protein, AV000670 Protein, PP5/TFPI-2 Protein, tissue factor pathway inhibitor 2 L homeolog Protein, tissue factor pathway inhibitor 2 Protein, tfpi2.L Protein, TFPI2 Protein, tfpi2 Protein, Tfpi2 Protein
- Background
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Abbreviation: TFPI2
Target Synonym: Tissue Factor Pathway Inhibitor 2,TFPI-2,Placental Protein 5,PP5,TFPI2
Background: Tissue factor pathway inhibitor-2 (TFPI2), a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). It is a 32 kDa matrix-associated glycoprotein consisting of a short amino-terminal region, three tandem Kunitz-type domains and a positively charged carboxy-terminal tail. TFPI2 inhibits plasmin-dependent activation of several metalloproteinases. TFPI2 is highly abundant in the full-term placenta and widely expressed in various adult human tissues, such as the liver, skeletal muscle, heart, kidney, and pancreas. The expression of TFPI2 in tumors is inversely related to an increasing degree of malignancy, which may suggest a role for TFPI2 in the maintenance of tumor stability and inhibition of the growth of neoplasms. TFPI2 inhibits the tissue factor/factor VIIa (TF/VIIa) complex and a wide variety of serine proteinases including plasmin, plasma kallikrein, factor Xia, trypsin, and chymotrypsin. TFPI2 is involved in regulating pericellular proteases implicated in a variety of physiologic and pathologic processes including cancer cell invasion, vascular inflammation, and atherosclerosis. TFPI2 has also been shown to induce apoptosis and inhibit angiogenesis, which may contribute significantly to tumor growth inhibition.
- Molecular Weight
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Calculated MW: 25.74 kDa
Observed MW: 75 kDa
- UniProt
- P48307
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