Frataxin Protein (FXN) (AA 42-210) (His tag)

Catalog No. ABIN7505616

Product Details

Target: Frataxin (FXN)

Protein Type: Recombinant

Protein Characteristics: AA 42-210

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Frataxin protein is labelled with His tag.

Sequence: Leu42-Ala210

Characteristics: A DNA sequence encoding the Human FXN protein (Q16595) (Leu42-Ala210) was expressed with a C-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Frataxin (FXN)

Alternative Name: Frataxin (FXN Products)

Synonyms: zgc:158218 Protein, LOC100284365 Protein, BcDNA:AT09528 Protein, CG8971 Protein, DFH Protein, Dfh Protein, Dmel\\CG8971 Protein, X25 Protein, dfh Protein, CyaY Protein, FA Protein, FARR Protein, FRDA Protein, RGD1565754 Protein, Frda Protein, frataxin Protein, fxn Protein, LOC100284365 Protein, TVAG_182150 Protein, fh Protein, FTX1 Protein, FXN Protein, Fxn Protein

Background:

Abbreviation: Frataxin,FXN

Target Synonym: Frataxin,mitochondrial,Friedreich ataxia protein,FXN,FRDA,X25,Frataxin intermediate form

Background: Frataxin intermediate form can cleave by mitochondrial processing peptidase(MPP) to the mature frataxin. Frataxin is a nuclear-encoded mitochondrial protein highly conserved in prokaryotes and eukaryotes. Its deficiency was initially described as the phenotype of Friedreich's ataxia, an autosomal recessive disease in humans. Although several functions have been described for frataxin, that is, involvement in Fe-S cluster and heme synthesis, energy conversion and oxidative phosphorylation, iron handling and response to oxidative damage, its precise function remains unclear. Although there is a general consensus on the participation of frataxin in the maintenance of cellular iron homeostasis and in iron metabolism, this protein may have other specific functions in different tissues and organisms.

Molecular Weight:

Calculated MW: 18.48 kDa

Observed MW: 21 kDa

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size