FGF18 Protein (AA 1-207) (His tag)

Catalog No. ABIN7505614

Product Details

Target: FGF18 (Fibroblast Growth Factor 18 (FGF18))

Protein Type: Recombinant

Protein Characteristics: AA 1-207

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This FGF18 protein is labelled with His tag.

Sequence: Met1-Ala207

Characteristics: A DNA sequence encoding the Human FGF18 protein (O76093) (Met1-Ala207) was expressed with a C-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: FGF18 (Fibroblast Growth Factor 18 (FGF18))

Alternative Name: FGF-18 (FGF18 Products)

Synonyms: FGF-18 Protein, ZFGF5 Protein, D130055P09Rik Protein, fgf18 Protein, FGF18 Protein, fgf18l Protein, fibroblast growth factor 18 Protein, fibroblast growth factor 18a Protein, fibroblast growth factor 18b Protein, FGF18 Protein, Fgf18 Protein, fgf18a Protein, Tsp_09844 Protein, fgf18b Protein

Background:

Abbreviation: FGF-18

Target Synonym: Fibroblast growth factor 18,FGF-18,zFGF5,FGF18,UNQ420,PRO856

Background: Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Experiment datas identified FGF18 as a selective ligand for FGFR3 in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.

Molecular Weight:

Calculated MW: 22.66 kDa

Observed MW: 32 kDa

UniProt: O76093

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway