VEGF121 Protein (AA 1-147) (His tag)
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- Target See all VEGF121 Proteins
- VEGF121 (Vascular Endothelial Cell Growth Factor 121 (VEGF121))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-147
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This VEGF121 protein is labelled with His tag.
- Sequence
- Met1-Arg147
- Characteristics
- A DNA sequence encoding theHuman VEGF121 protein (P15692-9) (Met1-Arg147) was expressed with a C-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product VEGF121 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- VEGF121 (Vascular Endothelial Cell Growth Factor 121 (VEGF121))
- Alternative Name
- VEGF121 (VEGF121 Products)
- Background
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Abbreviation: VEGF121
Target Synonym: VEGF-A,Vascular permeability factor,VPF,VEGFA
Background: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform ', ' binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor.
- Molecular Weight
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Calculated MW: 17.2 kDa
Observed MW: 14 kDa,18 kDa
- UniProt
- P15692-9
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