KIR2DL1 Protein (AA 1-245) (His tag)
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- Target See all KIR2DL1 Proteins
- KIR2DL1 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-245
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KIR2DL1 protein is labelled with His tag.
- Sequence
- Met 1-His 245
- Characteristics
- A DNA sequence encoding the human KIR2DL1 (NP_055033.2) extracellular domain (Met 1-His 245) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 92 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- <1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product KIR2DL1 Protein
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Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1) protein (His-Avi Tag)
KIR2DL1 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1) protein (His-Avi Tag,Biotin)KIR2DL1 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1) (AA 1-374) protein (GST tag)KIR2DL1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- KIR2DL1 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 1 (KIR2DL1))
- Alternative Name
- KIR2DL1 (KIR2DL1 Products)
- Synonyms
- NKAT Protein, NKAT1 Protein, p58.1 Protein, CD158A Protein, KIR221 Protein, KIR-K64 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Protein, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 Protein, KIR2DL1 Protein
- Background
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Abbreviation: KIR2DL1,CD158a
Target Synonym: CD158A,KIR-K64,KIR221,NKAT,NKAT-1,NKAT1,p58.1,XXbac-BCX195L8.1,XXbac-BPG184J6.7
Background: Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.
- Molecular Weight
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Calculated MW: 26 kDa
Observed MW: 45 kDa
- UniProt
- P43626
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