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CD22 Protein (AA 24-331) (His tag)

CD22 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505557
  • Target See all CD22 Proteins
    CD22 (CD22 Molecule (CD22))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 24-331
    Origin
    • 23
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Source
    • 22
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This CD22 protein is labelled with His tag.
    Sequence
    Trp 24-Thr 331
    Characteristics
    A DNA sequence encoding the Rat CD22/Siglec-2 protein (D3ZD88) (Trp 24-Thr 331) was expressed with N-His.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CD22 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    12 months
  • Target
    CD22 (CD22 Molecule (CD22))
    Alternative Name
    CD22 (CD22 Products)
    Synonyms
    A530093D23 Protein, Lyb-8 Protein, Lyb8 Protein, SIGLEC-2 Protein, SIGLEC2 Protein, siglec-2 Protein, CD22 antigen Protein, CD22 molecule Protein, Cd22 Protein, CD22 Protein
    Background

    Abbreviation: CD22,Siglec-2

    Target Synonym: CD22 antigen,Cd22,

    Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

    Molecular Weight

    Calculated MW: 33.77 kDa

    Observed MW: 39 kDa

    UniProt
    D3ZD88
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