IGFBPI Protein (AA 26-272) (His tag)

Catalog No. ABIN7505552

Product Details

Target: IGFBPI (Insulin-Like Growth Factor Binding Protein 1 (IGFBPI))

Protein Type: Recombinant

Protein Characteristics: AA 26-272

Origin: Rat

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This IGFBPI protein is labelled with His tag.

Sequence: Ala 26-Asn 272

Characteristics: A DNA sequence encoding the Rat IGFBP1/IGFBP-1 protein (P21743) (Ala 26-Asn 272) was expressed with N-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: IGFBPI (Insulin-Like Growth Factor Binding Protein 1 (IGFBPI))

Alternative Name: IGFBP1 (IGFBPI Products)

Synonyms: cb656 Protein, igfbp1 Protein, IGFBP-1 Protein, MGC68538 Protein, afbp Protein, ibp1 Protein, pp12 Protein, igf-bp25 Protein, higfbp-1 Protein, IGFBP1 Protein, LOC100223208 Protein, LOC100305121 Protein, AFBP Protein, IBP1 Protein, IGF-BP25 Protein, PP12 Protein, hIGFBP-1 Protein, IGFBA Protein, insulin like growth factor binding protein 1 Protein, insulin-like growth factor binding protein 1a Protein, insulin like growth factor binding protein 1 S homeolog Protein, insulin like growth factor binding protein 1 L homeolog Protein, insulin-like growth factor binding protein 1 Protein, IGFBP1 Protein, igfbp1a Protein, igfbp1.S Protein, igfbp1.L Protein, igfbp1 Protein, LOC100305121 Protein, Igfbp1 Protein

Background:

Abbreviation: IGFBP1,IGFBP-1

Target Synonym: Insulin-like growth factor-binding protein 1,Igfbp1,IBP-1,IGF-binding protein 1,IGFBP-1

Background: The insulin-like growth factor binding protein (IGFBP) family consists of six structurally related proteins that bind IGF with high affinity. These proteins share conserved cysteine-rich N- and C- terminal regions that participate in IGF binding. IGFBPs regulate the bioavailability of IGFs and modulate their biological activities, both positively and negatively. Some IGFBPs also have intrinsic bioactivity that is IGF-independent. Post-transitional modifications of the IGFBPs, including glycosylation, phosphorylation and proteolysis, influence IGF binding affinities and tissue localization, affecting both the IGF-dependent and independent functions.

Molecular Weight:

Calculated MW: 27.06 kDa

Observed MW: 35 kDa

UniProt: P21743

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Growth Factor Binding