TGFB2 Protein (AA 331-442) (His tag)

Catalog No. ABIN7505540

Product Details

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Protein Type: Recombinant

Protein Characteristics: AA 331-442

Origin: Rat

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TGFB2 protein is labelled with His tag.

Sequence: Ala 331-Ser 442

Characteristics: A DNA sequence encoding the Rat TGF-beta 2/TGFB2 protein (Q07257) (Ala 331-Ser 442) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: TGFB2 (Transforming Growth Factor, beta 2 (TGFB2))

Alternative Name: TGF-beta 2 (TGFB2 Products)

Synonyms: LDS4 Protein, TGF-beta2 Protein, tgf-beta2 Protein, tgfb2-A Protein, BB105277 Protein, Tgf-beta2 Protein, Tgfb-2 Protein, TGF-beta 2 Protein, Tgfbr2T Protein, TGFB2 Protein, TGFbeta2 Protein, MGF Protein, TGF-B2 Protein, transforming growth factor beta 2 Protein, transforming growth factor beta 2 L homeolog Protein, transforming growth factor, beta 2 Protein, transforming growth factor, beta receptor 2 Protein, TGFB2 Protein, tgfb2.L Protein, Tgfb2 Protein, Tgfbr2 Protein, tgfb2 Protein

Background:

Abbreviation: TGF-beta 2,TGFB2

Target Synonym: BSC-1 cell growth inhibitor,cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF,polyergin,transforming growth factor beta-2

Background: TGF-beta 2 (transforming growth factor beta 2) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cysteine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-beta isoform has some non-redundant functions, for TGF-beta 2, mice with targeted deletion show defects in development of cardiac, lung, craniofacial, limb, eye, ear and urogenital systems. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. TGF-beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins. TGF-beta 2 signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II ser/thr kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates another ser/thr kinase receptor, TGF-beta RI (also called activin receptor-like kinase (ALK) -5), or alternatively, ALK-1. The whole complex phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for disparate actions observed in response to TGF-beta in different contexts.

Molecular Weight:

Calculated MW: 12.21 kDa

Observed MW: 13 kDa

UniProt: Q07257

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus