SERPINB2 Protein (AA 1-416) (His tag)

Catalog No. ABIN7505534

Product Details

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Protein Type: Recombinant

Protein Characteristics: AA 1-416

Origin: Rat

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SERPINB2 protein is labelled with His tag.

Sequence: Met 1-Pro 416

Characteristics: A DNA sequence encoding the Rat PAI-2 protein (P29524) (Met 1-Pro 416) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Alternative Name: PAI-2 (SERPINB2 Products)

Synonyms: HsT1201 Protein, PAI Protein, PAI-2 Protein, PAI2 Protein, PLANH2 Protein, SERPINB2 Protein, Planh2 Protein, ovalbumin Protein, Pai2a Protein, serpin family B member 2 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 2 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 2 Protein, SERPINB2 Protein, Serpinb2 Protein

Target Type: Amino Acid

Background:

Abbreviation: PAI-2

Target Synonym: HsT1201;PAI;PAI-2;PAI2;PLANH2

Background: Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB2 is a major product of activated monocytes and macrophages and is substantially induced during most inflammatory processes. Distinct from its widely described extracellular role as an inhibitor of urokinase plasminogen activator. SerpinB2 has been shown to have an intracellular role as a retinoblastoma protein (Rb)-binding protein that inhibits Rb degradation. SerpinB2 is widely described as an inhibitor of urokinase plasminogen activator. SerpinB2 inhibits urokinase-type plasminogen activator. The monocyte derived SerpinB2 is distinct from the endothelial cell-derived PAI-1. SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication.

Molecular Weight:

Calculated MW: 45.65 kDa

Observed MW: 45 kDa

UniProt: P29524

Pathways: Autophagy