S100A9 Protein (AA 2-113) (His tag)
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- Target See all S100A9 Proteins
- S100A9 (S100 Calcium Binding Protein A9 (S100A9))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-113
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Origin
- Rat
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This S100A9 protein is labelled with His tag.
- Sequence
- Ala2-Lys113
- Characteristics
- A DNA sequence encoding the Rat S100A9 (P50116-1) (Ala2-Lys113) was expressed with a polyhistidine tag at the N-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product S100A9 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- S100A9 (S100 Calcium Binding Protein A9 (S100A9))
- Alternative Name
- S100A9 (S100A9 Products)
- Synonyms
- 60B8AG Protein, CAGB Protein, CFAG Protein, CGLB Protein, L1AG Protein, LIAG Protein, MAC387 Protein, MIF Protein, MRP14 Protein, NIF Protein, P14 Protein, Mrp14 Protein, S100A9 Protein, MRP-14 Protein, p14 Protein, 60B8Ag Protein, AW546964 Protein, BEE22 Protein, Cagb Protein, GAGB Protein, L1Ag Protein, S100 calcium binding protein A9 Protein, S100 calcium binding protein A9 (calgranulin B) Protein, S100A9 Protein, S100a9 Protein
- Background
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Abbreviation: S100A9
Target Synonym: Protein S100-A9,Calgranulin-B,Calprotectin L1H subunit,Leukocyte L1 complex heavy chain,Migration inhibitory factor-related protein 14,MRP-14,p14,S100 calcium-binding protein A9,CAGB,CFAG,MRP14
Background: S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100 % soluble in ammonium sulfate at neutral pH . Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A9, also known as S100 calcium-binding protein A9, S100A9, and CAGB, is a member of the S-100 family. S100A9 is expressed by macrophages in acutely inflammed tissues and in chronic inflammation. It is also expressed in epithelial cells constitutively or induced during dermatoses. It has anti-microbial activity towards bacteria and fungi. The anti-microbial and proapoptotic activity of S100A9 is inhibited by zinc ions. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide. It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. S100A9 plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
- Molecular Weight
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Calculated MW: 13.01 kDa
Observed MW: 15.24 kDa
- UniProt
- P50116-1
- Pathways
- Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins
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